This document summarizes the production process of a biological pesticide made from Neem (Azadirachta indica) fruits, a sustainable and cost-effective plant protection solution developed under the IADA Project in Siem Reap, Cambodia. The process consists of four main technical stages: harvesting ripe fruits, drying them for 20–35 days, grinding them into fine powder, and packaging, with moisture control being the key factor for preserving product quality for up to one year. The pesticide solution is prepared by soaking Neem powder in water and adding an emulsifier (soap) to improve adhesion, while application rates and spraying frequency are adjusted according to preventive or curative purposes. This approach enables farmers to replace expensive chemical pesticides with locally available resources while promoting biodiversity and safeguarding peri-urban agricultural ecosystems.